supplement

Cycloastragenol

Chemical structure of Cycloastragenol (PubChem CID 13943286)
Structure via PubChem
Half-life
12 h
Typical timing
morning
Food rule
either
Default unit
mg

Studied for

Overview

Cycloastragenol (CAG) is a triterpenoid saponin derived from *Astragalus membranaceus*, a traditional Chinese medicinal herb. It is structurally similar to astragaloside IV, another active compound found in astragalus. CAG has garnered significant interest for its potential role in longevity and anti-aging research, primarily due to its reported ability to activate telomerase, an enzyme responsible for maintaining telomere length. Telomeres are protective caps at the ends of chromosomes that shorten with each cell division, and their shortening is associated with cellular aging and age-related diseases. While *Astragalus membranaceus* has been used for centuries, research into isolated cycloastragenol is more recent, focusing on its specific biological activities. (PubChem, DrugBank)

Deep dive

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Known interactions

  • Category rule: glp1 × supplement
    Note

    GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.

    Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.

  • Category rule: supplement × medication
    Note

    Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).

    Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.

Frequently asked

Sources referenced

["PubChem", "DrugBank", "NIH Office of Dietary Supplements (ODS)", "MedlinePlus", "Cochrane Library"]

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

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Related benefits

Other compounds studied for the same benefits as Cycloastragenol.

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