Cycloastragenol (CAG) is a triterpenoid saponin derived from *Astragalus membranaceus*, a traditional Chinese medicinal herb. It is structurally similar to astragaloside IV, another active compound found in astragalus. CAG has garnered significant interest for its potential role in longevity and anti-aging research, primarily due to its reported ability to activate telomerase, an enzyme responsible for maintaining telomere length. Telomeres are protective caps at the ends of chromosomes that shorten with each cell division, and their shortening is associated with cellular aging and age-related diseases. While *Astragalus membranaceus* has been used for centuries, research into isolated cycloastragenol is more recent, focusing on its specific biological activities. (PubChem, DrugBank)
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.